As much as I like the idea of Editorial (I'm a huge Pythonista fan), I find I don't actually ever use it.
The reason is the handling of the shortcuts above the toolbar.
In Byword, for example, if you select some text and hit "#", it behaves like a word processor and increases the indentation level of the selection.
In Editorial, the selected text is replaced with the "#" character just like it would be in the Pythonista source editor.